Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis.
This review explores the pathogenesis of sepsis-associated encephalopathy, including its effects
on the blood-brain barrier, microglia activation, mitochondrial dysfunction, the inflammatory
medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia,
and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopathy
may allow the development of adjunctive therapies targeting its underlying mechanism and help develop