Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis

Author(s): Lina Zhao, Yanxia Gao, Shigong Guo, Xin Lu, Shiyuan Yu, Zeng Zheng Ge, Hua Dong Zhu, Yi Li*

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 20 , Issue 2 , 2021

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Graphical Abstract:


Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review explores the pathogenesis of sepsis-associated encephalopathy, including its effects on the blood-brain barrier, microglia activation, mitochondrial dysfunction, the inflammatory medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia, and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopathy may allow the development of adjunctive therapies targeting its underlying mechanism and help develop preventative strategies.

Keywords: Hyperammonemia, intestinal flora imbalance, inflammatory medium, neurotransmitters, sepsis-associated encephalopathy, mitochondrial dysfunction.

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Article Details

Year: 2021
Published on: 17 November, 2020
Page: [112 - 124]
Pages: 13
DOI: 10.2174/1871527319999201117122158
Price: $65

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