Colorectal cancer (CRC) is the third most common cancer and the second leading cause
of cancer related deaths in the world with an estimated number of 1.8 million new cases and about
881,000 deaths worldwide in 2018. The epidemiology of CRC varies significantly between different
regions in the world as well as between different age, gender and racial groups. Multiple factors
are involved in this variation, including risk factor exposure, demographic variations in addition to
genetic susceptibility and genetic mutations and their effect on the prognosis and treatment response.
In this mini-review, we discuss the recent epidemiological trend including the incidence
and mortality of colorectal cancer worldwide and the factors affecting these trends.
Keywords: Colorectal cancer, epidemiology, incidence, mortality, demographic, prognosis.
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