Anti-Ulcerogenic and Cytoprotective Effects of Saharian (Sidr) Honey from Algeria

Author(s): Noureddine Djebli, Mohammad Rais Mustafa, Merve Keskin*, Sevgi Kolayli

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24 , Issue 10 , 2021


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Abstract:

Aim and Objective: This study aimed at investigating the gastro-protective effects of Algerian Sahara (Sidr) honey from Apis mellifera intermissa against HCl/Ethanol-induced gastric ulcers in rats.

Materials and Methods: Total phenolic content, antioxidant activity and phenolic compounds were determined. Then, three groups of rats (control, HCl/ Ethanol-induced ulcer, and orally administered honey) were used for the determination of gastro-protective effect of Sidr honey.

Results: Total phenolic content, total flavonoid content, and DPPH activity of the honey sample were determined as 47.35±3.35 mg GAE/ 100 g, 2.13±0.17 mg QE/ 100 g, and 229.24±0.02 mg/mL, respectively. Oral pretreatment of rats with honey (1.2 g/Kg body weight orally at an interval of 2 days) protected gastric mucosa against HCl/Ethanol-induced damage by decreasing ulcer score, the volume and acidity of gastric juice and increasing pH.

Conclusion: These results were confirmed by the histological assessment, which demonstrated a significant gastro-protective activity of Saharian (Sidr) honey against HCl/Ethanol-induced stomach ulcer. Plasma tumor necrosis factor-α, IL-6 and PGE2 were also measured. Sahara honey significantly decreased the plasma TNF-α, PGE2, and IL-6 concentrations.

Keywords: Gastric ulcer, sahara honey, HCl/Ethanol, ulcer score, TNF, IL-6, PGE2.

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Article Details

VOLUME: 24
ISSUE: 10
Year: 2021
Published on: 16 November, 2020
Page: [1664 - 1670]
Pages: 7
DOI: 10.2174/1386207323999201117114008
Price: $65

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