Cancer is an uncontrolled malignant tumor growth taking place in any tissue of the body and attains
complex diversity which makes it difficult for oncologists to choose therapeutics. The changes leading to
formation of cancerous cells occur due to a series of molecular events. Now scientists are trying to understand the
various molecular processes that are involved in the growth of cancers. This article presents a brief account of
epigenetics with reference to DNA methylation and histone modification as an important contributor to the
formation of cancer cells. Drug targeting the epigenetic regulators has been considered for various types of
cancer. The enzymes in DNA methylation and histone modification, FDA approved clinical drugs along with the
challenges associated with the development of anti-cancer target based therapeutics are summarized.
Keywords: Cancer, chemotherapy, epigenetics, DNA methylation, histone modification, molecular therapeutics.
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