Background: Abdominal Aortic Aneurysm (AAA) remains a surgical challenge. There are
many recognizable markers associated with the formation of AAA. Previous experiments carried out
on animal models have shown a correlation between serum calprotectin and the occurrence of AAA.
Objective: This study aimed to evaluate the level of calprotectin as a potential diagnostic biomarker in
patients with diagnosed AAA.
Methods: The study group consisted of 75 patients aged 35-75 years assigned to two groups: a control
group (n=43) of healthy subjects without AAA and a study group (n=32) of patients with a diagnosed
AAA. The first calprotectin test was performed upon patient admission to the hospital, and the second
control test was performed after three months. The concentration of calprotectin in plasma was determined
using the Immunoenzymatic Method (ELISA) with the commercially available Assaypro Kit
(AssayMax™ Human Calprotectin ELISA Kit), as well as the sandwich method with polyclonal antibodies
to human calprotectin and peroxidase enzyme.
Results & Discussion: Serum calprotectin levels in AAA patients were three times higher than in
healthy subjects (p<0.05). A statistically significant twofold decrease in calprotectin concentration was
observed after AAA surgery compared to the control group (p<0.05).
Conclusion: Calprotectin levels can be an important marker in the detection of AAA. In conclusion,
AAA patients showed a threefold increase in serum calprotectin level and a twofold decrease in this
marker after AAA surgery.