Background: Leishmaniasis, a still important public health problem, exhibits
environmental risk factors such as massive migrations, urbanization, and deforestation.
WHO research for Leishmaniasis is mainly focused on the development of new tools,
such as diagnostic tests, drugs, and vaccines. During the drug development strategy, only
a few compounds were promising and call for further study after the in vitro and in vivo
Objective: In this review, our group aimed to highlight the utmost research done during
2014 to 2019 in the fields of natural and synthetic compounds, as well as repurposed
drugs and new formulations tested in vivo for Leishmania spp.
Method: Based on the literature search, we used the databases MEDLINE, PUBMED,
CAPES PERIODIC and ELSEVIER to delineate an interval of the last 5 years of research
on each field.
Results: Among the natural compounds tested, allicin and a fraction of potato tuber extract
showed the most promising antileishmanial activity. Concerning synthetic compounds,
quinolines, bornyl ester, thymol, benzoxaborole and nitroimidazole derivatives
exhibited encouraging results. Moreover, repositioned alternatives involved combinations
with known drugs and monotherapy protocols as well. In these years, new formulations
were widely assessed as drug delivery systems, such as nanoparticles, micelles and liposomes
in polymer conjugations.
Conclusion: Drug repurposing and new formulations of already-known drugs are worthwhile
approaches to promptly introduce new treatment schemes to Leishmaniasis. Nevertheless,
the interest in new synthetic compounds and new formulations brings light to new
treatment proposals and are notable lines of research.