Potential Role of In Vitro-In Vivo Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs

Author(s): Mohamed S.T.A. Azeeze*, Shanthi B. Santhosh, Murugesan S. Manjari, Subramania N. Meyyanathan

Journal Name: Current Drug Targets

Volume 22 , Issue 12 , 2021

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Graphical Abstract:


Background: Conventional medicines, along with herbal formulations of Chinese, serve as the primary source and hub of active new drugs where the initial research concentrates on the extraction and isolation of bioactive lead compound(s) to treat several diseases largely for cancer. Plant-derived natural products and their analogs reveal a significant source of several clinically useful anticancer agents. Herbs and herbal derived active compounds play an unavoidable role in the treatment, drug discovery and delivery for decades, as evidenced by numerous existing marked drugs and various cancer-related molecular targets in clinical development.

Objective: Solubility, resistance and metabolic limitations of the drug can be overcome by suitable molecular modifications. Due to enhancements in tumor targeting technology, some agents who failed in earlier clinical studies are also stimulating renewed interest. In this connection, In Vitro-In Vivo Correlation (IVIVC) plays an important role in the development of dosage forms in the field of pharmaceutical technology.

Conclusion: IVIVC tool fastens and improves the drug development process and product quality, which is also utilized in internal control for scale-up to improve formulations and alternative production processes. Most importantly, this IVIVC tool lessens the number of human studies during new pharmaceuticals developments. In this review, we would like to grab the attention of readers to the importance and significance of IVIVC for natural products of anticancer drugs examples such as Docetaxel, Etoposide phosphate, 6-Gingerol, Capsaicin, etc.

Keywords: Cancer, chemotherapy, In Vitro-In Vivo correlation (IVIVC), herbal drugs, anticancer agents, treatments.

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Article Details

Year: 2021
Published on: 12 November, 2020
Page: [1357 - 1375]
Pages: 19
DOI: 10.2174/1389450121999201113110433
Price: $65

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