Aim: To formulate and preliminary evaluated polysaccharide based
mucoadhesive floating tablets of Cinnarizine.
Background: Gastro-retentive drug delivery systems has proved to be a successful
approach to enhance the gastric residence with site specific targeting for
achieving local or generalized effect. Various patents has also been filed globally
employing gastro-retentive approach.
Objective: The study is designed to explore the mucoadhesive and low density
characteristics of corn fibre gum (CFG) for the preparation of gastro-retentive
floating tablets of cinnarizine.
Methods: Floating tablets were prepared by direct compression technique using
different concentrations of CFG (45, 50, 60% w/w). The formulated floating
tablet batches were evaluated for their hardness, friability, drug content, floating
duration/lag time, swelling behavior, bioadhesive strength and in-vitro drug release.
Results: Mucoadhesive strength was found to increase with an increment in the
polysaccharide concentration. Swelling index was found to increase both with
the increase in CFG concentration and with duration for which tablet remains in
medium. The in-vitro drug release studies indicated decrease in drug release
(91% to 77%) with the increase in polymer concentration. The release data was
further fitted to various kinetic models which revealed the drug release to be in
accordance with zero order and Higuchi models, indicating polymer to exhibit
the swellable matrix forming abilities. The value of n (between 0.458 and 0.997)
from Korsemeyer-Peppas model depicted the possibility of drug to follow more
than one mechanism of release from the formulation i.e. diffusion and erosion.
Stability studies revealed the preparations to retain their integrity and pharmaceutical
characteristics at variable storage conditions.
Conclusion: Thus from the research findings, CFG could be concluded to possess
potential binder, release retardant and mucoadhesive characteristics which
could be successfully employed for the formulation of gastro-retentive floating