Current Updates in Transdermal Therapeutic Systems and Their Role in Neurological Disorders

(E-pub Ahead of Print)

Author(s): Neelu Yadav, Ashu Mittal*, Javed Ali, Jagannath Sahoo

Journal Name: Current Protein & Peptide Science


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Abstract:

The transdermal therapeutic system presents an important role in the treatment of neuropathic pain. Transdermal drug delivery is considered an ideal therapeutic approach for the management of chronic neurological disorders in the elderly population, It is a simple to use, non-invasive and painless drug delivery system, which provides sustained therapeutic plasma levels of drug for an extended period. Moreover, it bypasses the first-pass metabolism of the active agent, improves bioavailability and reduces undesired adverse effects, which in turn improves patient compliance. Several transdermal delivery systems are currently under investigation for the treatment of Parkinson’s syndrome, Alzheimer’s disorders, and Neurological pain. Drug delivery via the transdermal route is proposed as an alternative remedy to overcome the drawbacks associated with the conventional dosage forms for chronic neurological disorders. The management of Alzheimer’s disease via transdermal drug administration exhibits the greatest therapeutic improvements in the treatment of cognition and global functioning among neuropathic patients. Technological breakthroughs in transdermal drug administration such as microreservior system, microneedles, metered-dose transdermal spray (MDTS), needle-free injections, ultrasound-based transdermal therapeutic systems have been successfully used to treat neurological disorders. For example microneedle (MN) is a highly efficient and versatile device due to its distinctive properties. Ultrasounds have been very popular for the delivery of bioactive agents across the skin barrier. This review focuses on the recent advances of various technologies employed in the transdermal therapeutic systems and its applications towards neurological disorders for achieving patient therapeutic outcomes.

Keywords: Transdermal delivery, novel enhancers, neurological disorders, nanotechnologies.

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Article Details

Published on: 11 November, 2020
(E-pub Ahead of Print)
DOI: 10.2174/1389203721999201111195512
Price: $95

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