Title:Pharmacokinetic Research Progress of Anti-tumor Drugs Targeting for Pulmonary Administration
VOLUME: 21 ISSUE: 14
Author(s):Mengfan Zhao, Ziwei Jing, Lin Zhou, Hongyu Zhao, Qiuzheng Du* and Zhi Sun*
Affiliation:Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan,, Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan,, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan,, Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan
Keywords:Lung cancer, inhalation preparation, drug carrier, pharmacokinetics, anti-tumor drugs, pulmonary administration.
Abstract:Background: Cancer is a major problem that threatens human survival and has a high mortality rate.
The traditional chemotherapy methods are mainly intravenous injection and oral administration, but have obvious
toxic and side effects. Anti-tumor drugs for pulmonary administration can enhance drug targeting, increase
local drug concentration, and reduce the damage to systemic organs, especially for the treatment of lung cancer.
Methods: The articles on the pharmacokinetics of anti-tumor drugs targeting pulmonary administration were retrieved
from the Pub Med database. This article mainly took lung cancer as an example and summarized the
pharmacokinetic characteristics of anti-tumor drugs targeting for pulmonary administration contained in nanoparticles,
dendrimers, liposomes and micelles.
Results: The review shows that the pharmacokinetics process of pulmonary administration is associated with a
drug carrier by increasing the deposition and release of drugs in the lung, and retarding the lung clearance rate.
Among them, the surface of dendrimers could be readily modified, and polymer micelles have favorable loading
efficiency. In the case of inhalation administration, liposomes exhibit more excellent lung retention properties
compared to other non-lipid carriers. Therefore, the appropriate drug carrier is instrumental to increase the
curative effect of anti-tumor drugs and reduce the toxic effect on surrounding healthy tissues or organs.
Conclusion: In the process of pulmonary administration, the carrier-embedded antitumor drugs have the characteristics
of targeted and sustained release compared with non-packaging drugs, which provides a theoretical basis
for the clinical rational formulation of chemotherapy regimens. However, there is currently a lack of comparative
research between drug packaging materials, and more importantly, the development of safe and effective
anti-tumor drugs targeting for pulmonary administration requires more data.
