Aims and Objective: Synthesis of novel bis-spirooxindoles was carried out from isatins, two equivalents
of malononitrile, and various derivatives of cyclohexanones.
Background: A facile one-pot and four-component reaction was investigated for the synthesis of novel bisspirooxindoles
from different derivatives of isatins, two equivalents of malononitrile and various derivatives of
cyclohexanone in the presence of magnetic CoFe2O4@MCM-41@MgO NPS catalyst under mild conditions.
Materials and Methods: Firstly, the magnetic CoFe2O4@MCM-41@MgO was prepared in three steps. Afterwards,
the CoFe2O4@MCM-41@MgO was used as a base catalyst for the one-pot synthesis of bisspirooxindoles.
Results and Discussion: The procedure exhibited several benefits, an excellent yield of products, short reaction
times, reusability, and recyclability of the nanocatalyst.
Conclusion: The structure of nanocatalyst was recognized by FT-IR, XRD, VSM, SEM, BET, and EDX techniques,
and the structure of the organic products was determined by melting point, FT-IR, 1H NMR, 13C NMR,
Mass spectra, and C.H.N analyses.