Recent Development of Novel HDAC6 Isoform-selective Inhibitors

Author(s): Yunpeng Zhao, Tao Liang, Xuben Hou*, Hao Fang*

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 21 , 2021


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Abstract:

As an important post-transcription modification, histone deacetylation plays significant roles in chromatin remodeling and gene expression. The aberrant modification of histone deacetylation leads to various diseases. As a critical member of histone deacetylase (HDAC), HDAC6 serves as a key modulator in many physiological processes. Abnormal expression of HDAC6 gives rise to cancer, neurodegeneration and other diseases. Here, we have reviewed recent advances in physiological, protein structure and development of HDAC6 selective inhibitors.

Keywords: post-transcription modification, HDAC6, structure, cancer, selective inhibitor, histone deacetylation.

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Article Details

VOLUME: 28
ISSUE: 21
Year: 2021
Published on: 11 November, 2020
Page: [4133 - 4151]
Pages: 19
DOI: 10.2174/0929867327666201111142653
Price: $65

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