Research Progress on circRNA in Nervous System Diseases

Author(s): Nana Ma, Wei Zhang*, Jun Wan*

Journal Name: Current Alzheimer Research

Volume 17 , Issue 8 , 2020


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Abstract:

Circular RNAs (circRNAs) are a kind of non-coding RNA molecule with highly stable circular structures. CircRNAs are primarily composed of exons and/or introns. Recently, a lot of exciting studies showed that circRNA played an essential role in the development of nervous system diseases. Here, classification, characteristics, biogenesis, and the association of circRNA dysregulation with nervous system diseases, such as Alzheimer’s disease, are summarized. The review not only contributes to a better understanding of circRNAs, but also provides new research directions toward the diagnosis, treatment, and prevention of nervous system diseases.

Keywords: Circular RNA, non-coding RNA, nervous system, disease, Alzheimer's disease, Parkinson disease.

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Article Details

VOLUME: 17
ISSUE: 8
Year: 2020
Published on: 24 December, 2020
Page: [687 - 697]
Pages: 11
DOI: 10.2174/1567205017666201111114928
Price: $65

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