Potential Implications of Black Seed and its Principal Constituent Thymoquinone in the Treatment of COVID-19 Patients

Author(s): Masood Alam Khan*, Hina Younus

Journal Name: Current Pharmaceutical Biotechnology

Volume 22 , Issue 10 , 2021


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Abstract:

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of the current pandemic of Coronavirus Disease-2019 (COVID-19). The progression of COVID-19 is related to an excessive host inflammatory immune response to SARS-CoV-2 infection, which is considered a major cause of disease severity and death. Dysregulated immune response produces huge amounts of pro-inflammatory cytokines and chemokines called "cytokine storm". Moreover, the activation of microthrombi formation plays an important role in multiple organ failure.

Methods: Keeping into consideration the potent anti-inflammatory activity of black seed and its major constituent Thymoquinone (TQ), we hypothesize their potential implication in the treatment of COVID-19 patients. A literature search was performed in PubMed, ScienceDirect, Google Scholar and Scopus electronic databases using the terms, including black seed, N. sativa, thymoquinone, SARSCoV- 2, COVID-19 and inflammatory immune response.

Results: Various studies confirmed that Black seed and TQ reduced the thrombus formation, the expression of tissue factor and the immune activation. Furthermore, TQ demonstrated the broad-spectrum antimicrobial activity that may be effective in controlling the secondary infections in COVID-19 patients.

Conclusion: Keeping into consideration the multi-targeting nature of the black seed and TQ, they may be used as a potential therapeutic formulation or as an adjunct therapy in the treatment of COVID-19 patients.

Keywords: COVID-19, SARS-CoV-2, immunopathogenesis, thymoquinone, cell signaling pathways, secondary infections.

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Article Details

VOLUME: 22
ISSUE: 10
Year: 2021
Published on: 10 November, 2020
Page: [1315 - 1324]
Pages: 10
DOI: 10.2174/1389201021999201110205048
Price: $65

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