Introduction: Hepatic steatosis is a frequent condition that afflicts, especially, obese and
insulin-resistant patients. Diagnosis is usually made through imaging tests. Despite the high prevalence
and risk of complications, there is no specific treatment approved, though a vast number of
medications have been tested.
Objective: This study aimed to determine the efficacy of dipeptidyl peptidase IV inhibitors (i DPP-
IV) in the treatment of NAFLD.
Methods: We searched the electronic databases of the Cochrane Library, MEDLINE, EMBASE,
and LILACS, as well as reference lists of the included studies and grey literature; 9 studies were selected
Results: 7 studies were used for metanalysis for 3 outcomes. i DPP-IV showed an ALT-reducing
power of MD -10.83 (95% CI 35.23 to 13.57) at 3 months and MD -9.27 (95% CI 10.92 to -7.62)
at 6 months of intervention, as well as a reduction of hepatic steatosis via MRI of SMD 0.10 (95%
CI 0.31 to 0.50); the overall incidence of adverse events was very low. The studies were considered
of low and very low quality by the GRADE evaluation.
Conclusion: Because of the overall poor quality of the studies and heterogeneity of the population
analyzed, i DPP-IV did not show efficacy on inflammatory markers or fibrosis in patients with