Metabolic syndrome (MetS) which is caused by poor dietary habits and sedentary behavior is a serious global health problem.
MetS is a cluster of risk factors, represented by central obesity, hyperglycemia, dyslipidemia, and hypertension. In the 21st century, MetS and
associated comorbidities, including obesity, diabetes and cardiovascular diseases, are the major threats to human health. Practical dietary
strategies, nutritional bioactive compounds and a healthy lifestyle are claimed to be efficient in the management of one or more components
of MetS. Nevertheless successful management of MetS and commodities is still a major concern. Since hyperglycemia, inflammation and
redox imbalance are intrinsically involved in the progression of MetS comorbidities, finding effective strategies that precisely target these
systems is highly warranted. In this scenario, pharmacological and non-pharmacological approaches with or without dietary patterns, phytochemicals
or exercise interventions are the practical strategies to combat MetS and associated diseases. However, designing and prescribing
of optimal nutritional patterns and exercise regimens remains a big challenge to achieve the maximum beneficial effects. This thematic issue
addressed the concerns and provided practical strategies to overcome the malady of MetS in the modern world.