Background: 1,8-diaminonaphthalen (1,8-DAN) with special organic structure was
applied in organic synthesis to provide efficient complex scaffolds, through the two or fourcomponent
fashion. This review highlights its recent application in organic reactions under
different conditions and heterogynous catalysts to produce various molecules, which were used as
medicines, sensors, and dyes.
Objective: 1,8-diaminonaphthalene (1,8-DAN) is a bicyclic compound with two amino groups
which has received much attention in organic chemistry due to their medicinal activities such as
antifungal, antimicrobial, antiulcer, antitumor, oxidation dyestuff, hair color, fluorescent, and
chemo-sensors. In continuation of our studies, herin, recent application of 1,8-DAN in organic
synthesis was reviewed.
Conclusion: In conclusion, the application of 1,8-DAN 1 in different reactions was reviewd
through the various conditions to yield the target compounds with high medicinal activities, and
potential for sensitive detection of different ions. The target compounds including 1,8-DAN 1 with
various structures were provided such as perimidines, perimidinones, aminonaphthalenes which
were produced through different methods as brought for further study in this review.