Abdominal Organ Enhancement in Dynamic MRI using 1 M Gadobutrol vs 0.5 M Meglumine Gadoterate in Liver of Hemangioma Patients

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Author(s): Kazuhiro Saito*, Yoichi Araki, Reiji Kokubo, Chishio Kurata, Yukari Wakabayashi, Kunihito Suzuki

Journal Name: Current Medical Imaging
Formerly: Current Medical Imaging Reviews

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Objectives: To evaluate the differences in contrast enhancement of abdominal organ on abdominal dynamic MRI using 0.1 mmol/kg 1.0M gadobutrol (GAD) versus 0.5M meglumine gadoterate (MG) in patients having liver hemangioma.

Materials and methods: Phantom study was performed with different concentration (0.05, 0.1, 0.3, 0.5, 0.7, 0.9, 1.0, 5.0 and 10 mmol/L) of GAD and MG. Sixty-two patients with liver hemangioma were enrolled. Contrast media were injected a rate of 2mL/s and the 40mL of saline followed. Monitoring scan was used for acquiring arterial phase. Two arterial phases, portal and equilibrium phase were obtained. One certified radiologist set region of interests on abdominal aorta, liver, pancreas, spleen, liver hemangioma. The relative enhancement ratio (RER) was calculated.

Results: In phantom study, the signal intensity of both contrast media was similar in lower concentration, however, signal intensity of MG was higher in more than 5.0 mmol/L. In clinical study, the RER of abdominal viscera on portal and equilibrium phase were higher in GAD. Hemangioma showed higher on equilibrium phase in GAD. The aortic RER did not show significant difference in all phases and liver RER on 2nd arterial phase showed much higher in GAD. Arterial phase in GAD might have been late for optimal timing.

Conclusions: When same injection protocol used for abdominal dynamic MRI, arterial phase became late in case of using GAD. The higher T1 relaxivity value showed significant higher enhancement in abdominal viscera on portal phase and equilibrium phase and hemangioma showed also significant higher enhancement on equilibrium phase.

Keywords: Abdomen, contrast media, hepatobiliary imaging, magnetic resonance imaging, arterial phase, liver hemangioma

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(E-pub Ahead of Print)
DOI: 10.2174/1573405616999201109215827
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