Over the past several decades, plant-derived products (phytochemicals) have been suggested to possess immense
therapeutic potential. Among these phytochemicals, different flavonoids have been reported for their potent anticancer activity. To exhibit their anticancer potential, these flavonoids modulate different signaling pathways. Among these pathways,
the mammalian target of rapamycin (mTOR) and associated phosphatidyl-inositiol 3-kinase (PI3K)/protein kinase B
(Akt) signaling cascade has been suggested as a pivotal modulator of cell survival, proliferation, and death/apoptosis.
Hence, targeting this cascade could be an ideal strategy to alleviate apoptosis and inhibit proliferation in different forms of
cancer. The targeting of PI3K/Akt/mTOR by flavonoids have been well documented in the scientific literature. In the current communication, we have covered the anticancer potential of various flavonoids especially flavones, flavanols, and isoflavones that include apigenin, luteolin, biacalein, tangeretin, epigallocatechin-3-gallate, genistein, and diadzein especially
dealing with mTOR targeting.