Neuropeptides are endogenous active substances that play important roles in a number
of physiological processes and are ubiquitous in the nervous tissue in vivo. The gene encoding pedal
peptide/orcokinin-type (PP/OK-type) neuropeptide is an important member of the neuropeptide
gene family and is ubiquitous in invertebrates of Bilateria; orcokinin (OK) is mainly found in
Arthropoda, while pedal peptide (PP) is mainly found in Mollusca. OK and PP are also present in
other animals. PP/OK-type neuropeptides are a kind of multifunctional neuropeptides predominantly
expressed in the nervous tissue and play important roles in the nerve regulation of movement.
Moreover, OK has a number of other physiological functions. This review describes the distribution,
expression, function and maturation of PP/OK-type neuropeptides to facilitate investigations
of new functions and receptors of PP/OK-type neuropeptides, providing the theoretical foundation
for the potential use of PP/OK-type neuropeptides in the prevention and control of agricultural and
forestry pests, as an additive for skin care products and in the screening of drugs for the treatment
Keywords: Neuropeptide, pedal peptide, orcokinin, multi-function, neuroregulation, diabetes.
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