Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations

Author(s): Sukriti Vishwas, Monica Gulati, Bhupinder Kapoor, Saurabh Gupta*, Sachin Kumar Singh*, Ankit Awasthi, Arzoo Khan, Aditya Goyal, Anil Bansal, Suman Baishnab, Thakur Gurjeet Singh, Sandeep Arora, Omji Porwal, Ankit Kumar, Vijay Kumar

Journal Name: Current Neuropharmacology

Volume 19 , Issue 7 , 2021


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Abstract:

Huntington’s disease (HD) is an autosomal fatal genetic disease in which degeneration of neuronal cells occurs in the central nervous system (CNS). Commonly used therapeutics are cludemonoamine depletors, antipsychotics, antidepressants, and tranquilizers. However, these drugs cannot prevent the psychotic, cognitive, and behavioral dysfunctions associated with HD. In addition to this, their chronic use is limited by their long-term side effects. Herbal drugs offer a plausible alternative to this and have shown substantial therapeutic effects against HD. Moreover, their safety profile is better in terms of side effects. However, due to limited drug solubility and permeability to reach the target site, herbal drugs have not been able to reach the stage of clinical exploration. In recent years, the paradigm of research has been shifted towards the development of herbal drugs based nanoformulations that can enhance their bioavailability and blood-brain barrier permeability. The present review covers the pathophysiology of HD, available biomarkers, phytomedicines explored against HD, ongoing clinical trials on herbal drugs exclusively for treating HD and their nanocarriers, along with their potential neuroprotective effects.

Keywords: Huntington's disorder, oxidative stress, herbal medicine, neuroprotective effects, blood-brain barrier, nanocarriers.

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Article Details

VOLUME: 19
ISSUE: 7
Year: 2021
Published on: 08 November, 2020
Page: [957 - 989]
Pages: 33
DOI: 10.2174/1570159X18666201109090824
Price: $65

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