Background: Dengue virus is a potential source of propagating dengue hemorrhagic fever. This
virus leads to dengue hemorrhagic fever/dengue shock syndrome, benign syndrome, and severe syndrome and
due to its infection, there occurs alterations at multiple levels such as gene expression and pathway levels. So, it
is critical to understand the pathogenesis of dengue infection in terms of gene expression and the associated
Methods: For this purpose, here, we have analyzed the temporal gene expression profiling for the dengue hemorrhagic
fever dataset at 12, 24, and 48 hours.
Results: The outcome appears that the dengue hemorrhagic fever evolves differently at different time periods
Conclusion: The change in the gene expression pattern increases exponentially from 12 hours to 48 hours and
the number of altered functions (pathways) also increases. Wnt, apoptosis, and transcription signaling are
among the critical pathways which are dominantly altered. In the initial phase (first 12 hours), only two pathways
are altered due to dengue infection, while in the next 12 hours, eight pathways are altered, and finally, in
the next 24 hours, 11 pathways are altered and most of these 11 pathways are very critical in terms of biological
pathways and functions.