Background: The genus Morus is one of the rich sources of phytomedicine and considered
a beneficial natural source for drugs with potential antimicrobial effect under the traditional
system of medicine.
Introduction: In the present study, three bioactive compounds isolated from the leaves of two species
of genus Morus and their antibacterial effect against selective pathogens were assessed.
Methods: The inhibitory effects of the three molecules isolated were assessed for their minimum
inhibition concentration (MIC) and minimum bactericidal concentration (MBC) against selected
pathogens. The in-silico studies provided the toxicity profile and the binding interactions with glucosamine-
6-phosphate synthase for all the isolates.
Results: Among the three compounds tested, cathafuran-B showed a prominent bacteriostatic and
bactericidal effect, which is supported by the results of in-silico analysis suggesting that cathafuran-
B could be a potential glucosamine-6-phosphate synthase inhibitor.
Conclusion: The biomolecule isolated from less explored Morus laevigata exhibiting higher antibacterial
effect among the compounds tested warranted opening a new prospect in phytomedicinal
research for exploring its pharmacological properties and lowering the utilization load present on
highly explored Morus alba.