Background: This article concentrates on the processes occurring in the medium around the cancer
cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of
natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and
associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semiempirical
methods, are considered.
Objective: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have
adapted to take food containing nitrile glycosides and/or modified forms to counteract "external" bioactive
activity. For their part, cancers have evolved to create conditions around their cells that eliminate their active
apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract
it. In this way, it protects itself and the gene sets and develops accordingly.
Methods: Pedestal is derived that closely defines the processes of hydrolysis in the blood, the transfer of a
specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent densityfunctional
quantum-chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to
bioactive forms causing chemical apoptosis of the cell-independent of its non-genetic set, which seeks to
counteract the process.
Results: Used in oncology, it could turn a cancer from a lethal to a chronic disease (such as diabetes). The
causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer
cells could be kept low for a long time (even a lifetime).
Conclusion: The amide derivatives of nitrile glycosides exhibit anticancer activity; the cancer cell probably
seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and
the amide-carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer
cell itself and thus block and/or permanently damage its normal physiology.