Advances in Organic Synthesis

Advances in Organic Synthesis

Volume: 13

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent ...
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Remarkable Advances in the Asymmetric Synthesis of Biologically Active Natural Compounds from the Advent of Chiral Auxiliaries

Pp. 1-51 (51)

Gaspar Diaz-Muñoz, Izabel Luzia Miranda, Suélen Karine Sartori, Daniele Cristina de Rezende, Jefferson Viktor Barros de Paula Baeta, Fernanda Rodrigues Nascimento and Marisa Alves Nogueira Diaz


This chapter reports advances in synthetic methodologies employing chiral auxiliaries for the stereoselective synthesis of biologically active natural molecules. Derivatives of naturally occurring compounds such as amino acids, carbohydrates, and terpenes, chiral auxiliaries have been described as an essential aid for the construction of highly complex molecules. Among these auxiliaries, we highlight those of Evans, Corey, Yamada, Enders, Oppolzer, Kunz, Meyers, and Schöllkopf, whose contributions led to a remarkable progress in asymmetric synthesis in the last decades and continue to bring advances until the present day.


Asymmetric Synthesis, Biologically Active Compounds, Chiral Auxiliaries, Corey’s Chiral Auxiliary, Evans’ Oxazolidinones, Enders, Kunz, Meyers, Oppolzer, Schöllkopf, Yamada.


Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.