Neurodegenerative diseases are caused by progressive lesions or loss of specific nerve
cells, which endanger human health. However, the mechanism by which neurodegeneration manifests
remains unclear. Proteomics can shed light on this question as well as help establish diagnostic
standards and discover new drug targets. The power of proteomics for understanding neurodegenerative
diseases has increased substantially with the application of iTRAQ and TMT labeling
techniques. This review focuses on progress in these labeling techniques and their applications in
Keywords: Neurodegenerative diseases, iTRAQ, TMT, proteomics, quantitative neuroproteomics, neuro-imaging.
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