Beta-Blockers and Abdominal Aortic Aneurysm Growth: A Systematic Review and Meta-Analysis

Author(s): Juan A. Siordia*

Journal Name: Current Cardiology Reviews

Volume 17 , Issue 4 , 2021

Article ID: e230421187502
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Graphical Abstract:


Background: Aortic aneurysms are worrisome because of their predisposition to dissection and rupture. Beta-blockers are considered first-line therapy for aortic aneurysms. The following meta-analysis assesses if beta-blockers diminish aortic aneurysm growth.

Methods: A literature search was performed to collect information on clinical trials that have assessed aortic aneurysm growth between beta-blockers and placebo. The primary endpoint was aortic aneurysm growth rate per year. A forest plot with a random-effects model was used for analysis.

Results: Eight clinical trials were included in the analysis. Beta-blockers showed a statistically non-significant effect on aortic aneurysm growth (standard mean difference -0.44; 95% CI [-0.44, 0.00]).

Conclusion: Beta-blockers do not significantly influence aortic aneurysm growth. Further studies are required to find a suitable medical therapy to reduce growth rates.

Keywords: Beta-Blocker, aortic aneurysm, aorta, medical therapy, blood pressure, meta-analysis.

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Article Details

Year: 2021
Published on: 02 November, 2020
Article ID: e230421187502
Pages: 5
DOI: 10.2174/1573403X16999201102213619
Price: $65

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PDF: 132