Amongst the various diseases on a global scale, the second leading cause of mortality
and morbidity is ischemic stroke due to the unavailability of an effective therapy. With the growing
occurrence and its related health risks along with the absence of effective therapeutics, ischemic
stroke demands the continued and intensive research to explore effective and safe therapeutics. These
therapies may positively affect the numerous pathways associated with neuroprotection, thus,
extending the advantages to a larger population of stroke patients. Several preclinical studies employing
neuroprotectants have shown promising outcomes, but failed in clinical trials either because
of the lack of safety or efficacy. The Blood-Brain Barrier (BBB) restricts the delivery of various
potent neuroprotectants to the specific areas of the brain. The application of nanovehicles for
the delivery of drugs in the brain, however, could revolutionize the treatment of ischemic stroke.
These nanovehicles loaded with the drug could readily traverse the BBB via carrier, receptor and
adsorptive-mediated endocytosis into the brain without compromising the integrity of the BBB. Recent
advances in neuronanotherapeutics have resulted in improved neuronal regeneration and recovery
after ischemic stroke. In this review, we have attempted to discuss unexploited neuronanotherapeutics
potentials to treat and manage ischemic stroke.