Iron Oxide Nanoparticles Synthesized Via Green Tea Extract for Doxorubicin Delivery

Author(s): Lei Nie*, Chenlei Cai, Meng Sun, Fang Zhang, Lingyun Zheng, Qi Peng, Amin Shavandi*, Shoufeng Yang

Journal Name: Current Nanoscience

Volume 17 , Issue 4 , 2021


Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Abstract:

Background: Due to the limitation of conventional cancer treatment using chemotherapy, the nanoparticle therapeutics have shown enhanced efficacy with alleviating side effects.

Objective: The aim of this study was to prepare the superparamagnetic iron oxide nanoparticles (TC- SPION) for doxorubicin (DOX) loading and delivery.

Methods: Here, we reported a simple green strategy to fabricate T-C-SPION using green tea extract and citric acid. Also, the anti-cancer drug, DOX, was used as a model drug to fabricate DOX-loaded nanoparticles.

Results: The formed T-C-SPION nanoparticles were spherical with a diameter of 23.8 ± 0.8 nm, as confirmed by Transmission Electron Microscopy (TEM). Besides, Dynamic Light Scattering (DLS) revealed that the prepared nanoparticles were water-dispersible and stable while stored in water for 6 weeks. The CCK-8 assay showed T-C-SPION to have a good cytocompatibility using different iron concentrations (10 ~ 120 ug/mL). Furthermore, T-C-SPION had a higher DOX encapsulation efficiency (Eencaps), around 43.2 ± 1.8 %, which resulted in a lagged release profile of DOX, compared to other types of iron oxide nanoparticles using green tea or citric acid alone. Next, cell viability assay indicated that T-C-SPION with a higher Eencaps showed superior and sustained cytotoxicity compared to the control group.

Conclusion: The developed iron oxide nanoparticles synthesized by green tea extract and citric acid in this paper could be considered as a potential drug carrier for cancer therapy applications.

Keywords: Nanoparticles, iron oxide, green tea, citric acid, doxorubicin, drug delivery, cytocompatibility.

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 17
ISSUE: 4
Year: 2021
Published on: 29 October, 2020
Page: [646 - 657]
Pages: 12
DOI: 10.2174/1573413716999201029205654

Article Metrics

PDF: 151