Objective: In the present research article, we synthesized novel pregnane derivatives from 16-
dehydropregnenolone acetate (1) obtained by the degradation of naturally occurring plant productdiosgenin.
The oxime esters, 3β-acetoxy-pregn-5,16-diene, 20-one O-(2-(6-methoxynaphthalene-2yl)
propionyl) oxime (5) and 3β-hydroxy-pregn-5, 16-diene, 20-one O-(2-(4-isobutyl phenyl) propionyl)
oxime (6) have been synthesized by reaction of 3β-acetoxy-5,16-pregnadien-20-oxime (3) with NSAIDs
Ibuprofen and naproxen, respectively.
Methods: The epoxide derivative 3β-hydroxy-16α, 17α-epoxypregn-5-ene-20-one (4) was opened by
BF3.Et2O and yielding product 3,16-di-hydroxy pregn-5-ene-20-one (7) and 3,16,17-tri-hydroxy pregn-5-
ene-20-one (8), both the synthesized compounds underwent esterification with Ibuprofen affording 3,16-
di-(2-(4-isobutyl phenyl) propionoxy) pregn-5-ene-20-one (9) and 3,16-di-(2-(4-isobutyl phenyl)
propionoxy) 17-hydroxy pregn-5-ene-20-one (10), respectively.
Results: A one novel pregnane glycoside 3β-[2′,3′,4′,6′-tetra-O-acetyl-β-D-glucopy-ranosyl]-Oxy-20β-
hydroxy-16α-methoxy-pregn-5-ene (15) has also been synthesized from 3β, 20β-dihydroxy-16α-methoxypregn-
Conclusion: After the synthesis, all the compounds have been characterized by modern spectroscopic techniques.