The Function of LncRNA FTX in Several Common Cancers

Author(s): Yexiang Lin, Yujie Shen, Jinlan Chen, Chengyu Hu, Zixian Zhou, Chengfu Yuan*

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 20 , 2021


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Abstract:

Background: LncRNA is a kind of non-coding RNA and its research is more popular in recent years, which has more than 200 nucleotides. It plays a significant part in various biological functions, including chromosome modification, genome modification, transcriptional activation, transcriptional interference, and other processes. FTX, at the center of the X chromosome inactivation and it has been shown that lncRNA FTX regulates cancer cells’ development, migration, and invasion in many studies.

Methods: Relevant literature was collected through the PubMed system search and is summarized in this article.

Results: LncRNA FTX abnormally increased in tumor cells, such as liver cancer, stomach cancer, leukemia, renal cell carcinoma, colorectal cancer, glioma, osteosarcoma, etc. However, the expression level decreased in temporal lobe epilepsy, liver cirrhosis, heart failure, etc.

Conclusion: FTX may be an important regulatory factor and a potential therapeutic target in cancers.

Keywords: LncRNA FTX, cancer, temporal lobe epilepsy, cirrhosis, heart failure, osteosarcoma.

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Article Details

VOLUME: 27
ISSUE: 20
Year: 2021
Published on: 29 October, 2020
Page: [2381 - 2386]
Pages: 6
DOI: 10.2174/1381612826666201029164036
Price: $65

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