Clinically, probiotics have a significant role in nutrition, immune function, and maintenance
of gut homeostasis. Unfortunately, the widespread use of antibiotics disrupts the symbiotic balance of
gut microbiota, leading to the development of several gastrointestinal disorders. A recent study suggesting
a combination of appropriate probiotics and prebiotics through its ability to fix dysbiosis issues
has emerged as a potential alternative to treat various pathological conditions of the Gastrointestinal
Tract (GIT). Evidenced-based clinical research suggests that probiotic's effectiveness depends on several
factors including strain, dose, host immune system, underlying pathology, and duration of therapy.
Moreover, the microflora enriched medium reinforces the host defense against chemical and microbial
challenges. However, the limited information available to understand the molecular basis by which
probiotic maintains the gut homeostasis. The objective of this review to emphasize recent clinical outcomes
and possible mechanisms involved in probiotic action to combat the GIT disorders.