Background: Edible and medicinal plants are still an interesting source of promising biologically active
substances to drug discovery and development. At a time of increasing cancer incidence in the world, alleviating the
bothersome side effects of radiotherapy in debilitated cancer patients is becoming an important challenge.
Objective: The aim of the study was to overview the literature data concerning the radioprotective activity of extracts,
essential oils, and some chemical compounds obtained from 12 species belonging to the Lamiaceae family, gathering of
numerous spice and medicinal plants rich in valuable phytochemicals.
Results and Conclusion: The analysis of available publications showed radioprotective effectiveness of essential oils and
complex extracts containing phenolic acids and flavonoids in various in vitro and in vivo models. Relatively welldocumented preventive properties exhibited the following species: Mentha × piperita, Ocimum tenuiflorum, Origanum
vulgare, and Rosmarinus officinalis. However, few plants such as Lavandula angustifolia, Mentha arvensis, M. spicata,
Plectranthus amboinicus, Salvia miltiorrhiza, S. officinalis, Scutellaria baicalensis, and Zataria multiflora should be more
investigated in the future. Among the mechanisms of radioprotective effects of well-studied extracts and phytochemicals, it
can be mentioned mainly the protection against chromosomal damage, scavenging free radicals, decreasing of lipid
peroxidation and elevating of glutathione, superoxide dismutase, catalase, and alkaline phosphatase enzyme levels as well
as the reduction the cell death. The plant substances protected the gastrointestinal tract, bone marrow and lung fibroblasts.
In conclusion, studied species of Lamiaceae family and their active chemical compounds are potent in alleviating the side
effects of radiotherapy and should be considered as a complementary therapy.