Background: Cancer is defined as an abnormal/uncontrolled cell growth that shows rapid cell
division. This disease is annually recognized in more than ten million people. Nanomaterials can be used as new
strategies for cancer therapy. Nanostructured devices have been developed for drug delivery and controlled
release and created novel anticancer chemotherapies. Nanomaterials were taken into consideration because of
their new properties, containing a large specific surface area and high reactivity. Copper Oxide Nanoparticles
(CuONPs) have potential applications in many fields like heterogeneous catalysis, antibacterial, anticancer,
antioxidant, antifungal, antiviral, imaging agents, and drug delivery agents in biomedicine. CuONPs display
different physical properties, such as high-temperature superconductivity, electron correlation effects, and spin
dynamics. NPs can be synthesized using different methods like physical, chemical, and biological methods.
Methods: Copper Oxide Nanoparticles (CuONPs) have been suggested for its broad usage in biomedical
applications. In this review, we tried to exhibit the results of significant anticancer activity of green synthesized
CuONPs and their characterization by different analytical techniques such as UV-Vis, FT-IR, XRD, EDAX,
DLS, SEM, and TEM.
Results: The green method for the synthesis of CuO nanoparticles as eco-friendly, cost-effective, and facile
method is the more effective method. Synthesized CuONPs from this method have an appropriate size and shape.
The Green synthesized CuONPs exhibited high potential against several breast cancer (AMJ-13, MCF-7, and
HBL-100 cell lines), cervical cancer (HeLa), colon cancer (HCT-116), gastric cancer (human adenocarcinoma
AGS cell line), lung cancer (A549), leukemia cancer, and other cancers with the main toxicity approach of
increasing ROS production.
Conclusion: The present review confirms the importance of green synthesized CuO nanoparticles in medical
science especially cancer therapy that exhibited high activity against different cancer, both in vitro and in vivo.
The main toxicity approach of CuONPs is increasing the production of Reactive Oxygen Species (ROS). It needs
to perform more studies about in vivo cancer therapy and following clinical trial testing in the future. We believe
that green synthesized CuO nanoparticles can be used for the improvement of different diseases.