Molecular Mechanisms of Thymoquinone as Anticancer Agent

Author(s): Fatma Alhmied, Ali Alammar, Bayan Alsultan, Muruj Alshehri, Faheem Hyder Pottoo*

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24 , Issue 10 , 2021


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Abstract:

Thymoquinone (TQ), the bioactive constituent of Nigella Sativa seeds, is a well-known natural compound for the management of several types of cancers. The anti-cancer properties of thymoquinone are thought to be operated via intervening with various oncogenic pathways, prevention of inflammation and oxidative stress, inhibition of angiogenesis and metastasis, and induction of apoptosis, as well as up-regulation and down-regulation of specific tumor suppressor genes and tumor promoting genes, respectively. The proliferation of various tumor cells is inhibited by TQ via induction of cell cycle arrest, disruption of the microtubule organization, and downregulating cell survival protein expression. TQ induces G1 phase cell cycle arrest in human breast cancer, colon cancer and osteosarcoma cells through inhibiting the activation of cyclin E or cyclin D and up-regulating p27 and p21, a cyclin dependent kinase (Cdk) inhibitor. TQ concentration is a significant factor in targeting a particular cell cycle phase. While high concentration of TQ induces G2 phase arrest in human breast cancer (MCF-7) cells, low concentration causes S phase arrest. This review article provides mechanistic insights into the anticancer properties of thymoquinone.

Keywords: Thymoquinone, nigella sativa, angiogenesis, metastasis, invasion, cell cycle, inflammation, oxidative stress.

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Article Details

VOLUME: 24
ISSUE: 10
Year: 2021
Published on: 27 October, 2020
Page: [1644 - 1653]
Pages: 10
DOI: 10.2174/1386207323999201027225305
Price: $65

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