Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndromerelated
coronavirus-2 (SARS-CoV-2), has become an ongoing pandemic worldwide. However, there
are no vaccines or antiviral drugs with proven clinical efficacy. Therefore, a remedial measure is urgently
needed to combat the devastating COVID-19. The pharmacological activities of Nacetylcysteine
(NAC) and its potential functions in inhibiting the progression of COVID-19 make it a
promising therapeutic agent for the infection. In this mini-review, we discussed the therapeutic potential
of NAC in COVID-19 from the perspective of its multisite pharmacological actions.
Keywords: COVID-19, SARS-COV-2, N-acetylcysteine, oxidative stress, inflammation, thrombosis, nitric oxide, mental disorders.
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