Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio as Biomarkers for Cardiovascular Surgery Procedures: A Literature Review

Author(s): Raffaele Serra*, Nicola Ielapi*, Noemi Licastro, Michele Provenzano, Michele Andreucci, Umberto Marcello Bracale, Federica Jiritano, Stefano de Franciscis, Pasquale Mastroroberto, Giuseppe Filiberto Serraino

Journal Name: Reviews on Recent Clinical Trials

Volume 16 , Issue 2 , 2021

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Graphical Abstract:


Background: Neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been studied so far as prognostic factors of cardiovascular diseases. Their role interplayed with endothelial inflammation has emerged as optimal predictors for major cardiovascular disease events and prognostic factors for post-procedural outcomes.

Methods: A review of the current literature was undertaken to investigate the relationship between NLR and PLR with percutaneous, cardiac surgery, and vascular surgery procedures.

Results: Our findings show that perioperative NLR and PLR levels are significantly correlated with patient morbidity and mortality rates.

Conclusion: These biomarkers have several attractive characteristics, as they are inexpensive and quickly available, and they can contribute to the early identification of patients at high risk for periprocedural adverse events.

Keywords: Neutrophil-to-lymphocyte ratio, NLR, platelet-to-lymphocyte ratio, PLR, cardiac surgery, vascular surgery, precision medicine, outcome, surgery, endovascular.

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Article Details

Year: 2021
Published on: 07 May, 2021
Page: [173 - 179]
Pages: 7
DOI: 10.2174/1574887115999201027145406
Price: $65

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