Postmenopausal osteoporosis (PMO) is characterized by low bone mass and structural
deterioration of bone tissue with increased risk of fracture in postmenopausal women. It is due to
the deficiency of estrogen production after menopause, which causes the imbalance in the bone remodeling
process where resorption/formation skewed more towards resoption, which leads to bone
loss. It causes high morbidity and severe health complication among the affected women. The current
PMO therapy has many unwanted side effects and even increases the possibility of tumorigenesis.
Therefore, an alternative therapy that is safe and effective is required. Probiotics are dietary supplements
consisting of beneficial microbes and when administered in an adequate amount, confer a
health benefit to the host. Recent scientific evidences suggested the link between the intestinal microbiota
and bone health. This review discusses the process of bone remodeling and the role of intestinal
microbiota on the bone metabolism of the host. Further, it summarizes the recent studies of
probiotic on an animal model of PMO and also in post postmenopausal women.
Keywords: Postmenopausal osteoporosis (PMO, probiotics, bone remodeling, Gut microbiota, bone health, animal mode.
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