Non-alcoholic fatty liver (NAFLD) is a metabolic disorder characterized by an
excessive accumulation of fat in hepatocytes. It is a condition directly related to being overweight
and is considered as a manifestation of metabolic syndrome. The progressive increase in its
incidence due to the global increase in obesity, together with the absence of effective
pharmacological treatment, makes it necessary to find new strategies to reduce or reverse its
development and progression. In this sense, natural compounds can be potential targets for their
remarkable biological activity and low toxicity. Hydroxytyrosol (HT) is a phenolic compound
mainly found in olive oil and olive leaves with antioxidant, anti-inflammatory and cardiovascular
properties, among others.
This document analyses the available information on the potential beneficial effects of the
administration of HT against NAFLD.
Studies with animal models have shown promising results by reducing the degree of steatosis,
oxidative stress, inflammation, and improving liver function. The effects of HT derive from its
direct antioxidant and anti-inflammatory activity, but also from regulating the activity of various
The consumption of HT, preferably associated with virgin olive oil, combined with an adequate
diet and a healthy lifestyle, may be a strategy to consider preventing or reversing liver steatosis.
However, well-designed clinical trials are still necessary to determine their real effectiveness in