Introduction: Prostate cancer (Pc) is the most frequent neoplasia in men and the second
cause of death in Brazil.
Objective: To analyze the interactions and biologicals responses of Pc oxidative stress and prostatespecific
antigen (PSA), E-cadherin and MMP-13. Demonstrate whether the increase of the amount of
the form of E-cadherin found in the plasma of Pc patients, correlates with decrease of the PSA.
Methods: Samples were obtained through peripheral venipuncture to analyse parameters of biomarkers
pc as PSA, E-cadherin, MMP-13, Homocysteine, Folic acid, Vitamin B12, Testosterone T and free following
the patients diagnosis, 3 and 6 months during their treatment to analyze the biological responses
of Pc oxidative stress.
Results: The analysis was performed by using immunoenzymatic assay. Statistical data processed
through Excel in Windows Vista and analyzed through the Shapiro-wilk Test, ANOVA, and Spearman
Test. An increase in the concentration of E-cadherin (p = 0.02), as a decrease in concentration of PSA
(p < 0.001), total testosterone (p < 0.001) and free testosterone (p = 0.02) was observed during the
treatment period without significant alterations in the remaining markers for either of the periods.
Discussion: It was found that during treatment of men diagnosed with pc that there was an an increase
in the concentration of plasmatic E-cadherin, which was negatively correlated with the concentrations
of folic acid (-0,03 (0,87) rs (p). It was observed that the levels of hcy are positively correlated with
concentrations of total testosterone and a negative correlation. Vitamins B12 remained within the parameters
of normality during the entire study.
Conclusion: P.S.A levels were free and total testosterone levels decreased. In this way, monitoring the
folic acid, E-cadherin dosages of patients during the treatment phases can effectively complement in the
face of remission, since it would be a way of preventing abnormal cell replications, with a clinical view
prudent so that the cell methylation cycle is not affected.