Background: Nowadays, the breakthrough of COVID-19 pandemic around
the world is the biggest health challenge for the clinicians, and it represents an unexpected
effort to identify an effective treatment for those patients. No proven definitive therapies
for this infection currently exist. Unfortunately, the infected patients increased in an
alarming way every day, faster than medical evidence. At present, the expanding knowledge
regarding SARS-COV-2 virology provides several potential drug targets.
Objective: Therefore, clinicians need a rapid review and guideline about the main adverse
effects regarding the most prescribed drugs and, specifically, the efficacy and potential
risk of each pharmacological therapy, during hospital care.
Methods: The articles review was performed using PubMed to identify relevant papers in
English language reported through July 20th, 2020; a second review was performed using
Web of Science until August 28th, 2020. Due to the lack of randomized clinical trials,
we included case reports, case series and reviews. We found a total of 1606 related articles.
The authors independently reviewed the titles and abstracts for inclusion.
Conclusion: At present, despite the enormous medical effort for publishing several trials
or case reports, we have not yet discovered a definitive therapy against the COVID-19 infection.
This brief review aims to prompt identification of risk factors and main adverse
effects in a systematic view related to therapy with partial evidence proposed to date.