Efficacy of Short Term Topical Malva Sylvestris L. Cream in Pediatric Patients with Atopic Dermatitis: A Randomized Double-Blind Placebo-Controlled Clinical Trial

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Author(s): Mahshid Meysami, Mohammad Hashem Hashempur, Mohammad Kamalinejad, Majid Emtiazy*

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

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Background: Atopic dermatitis (AD) is a chronic inflammatory pruritic dermatologic disease in children. Malva sylvestris L. (M. sylvestris) is a medicinal plant which is used as a remedy for eczema in traditional Persian medicine. Previous studies have shown anti‐ulcerogenic and anti‐inflammatory activity of this plant.

Objectives: We designed a clinical trial to evaluate efficacy of topical cream of M. sylvestris extract in management of children with AD.

Methods: Fifty one children with AD were randomly enrolled in two arms of a randomized, double-blind, controlled clinical trial. They were treated by topical cream of M. sylvestris extract or placebo for a palm-sized surface (single fingertip unit, twice daily) for 4 weeks. The SCORing Atopic Dermatitis (SCORAD) score was set as the primary outcome measure.

Results: There was a significant improvement in the severity of participants’ dermatitis regarding skin thickening score, redness score, and total SCORAD score of the M. sylvestris group as compared with the placebo group (P= 0.009, P=0.01, and P=0.03; respectively).

Conclusion: According to the results of this clinical trial, it could be concluded that topical use of M. sylvestris extract cream was effective on the reduction of the AD symptoms in children.

Keywords: Malva sylvestris L., atopic dermatitis, complementary medicine, traditional Persian medicine, herbal medicine, integrative medicine

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(E-pub Ahead of Print)
DOI: 10.2174/1871530320666201023125411
Price: $95

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