Nanoparticles hold great promise in tumor targeting and molecular imaging because
they can co-deliver therapeutic drugs and imaging agents to the tumor site with a
single entity. Nanoparticles modified with ligands against moieties overexpressed on tumor
tissues have gained increasing attention due to their active targeting mechanisms.
Peptides are well suited for nanoparticle targeting modifications because they are small,
easy to synthesize and typically non-immunogenic. Herein, we review the peptide-modified
nanoparticles used for tumor targeting therapy and molecular imaging based on the
classification of peptide-targeting ligands. The development of targeting peptides and
nanoparticles will also be discussed.
Keywords: Peptide, nanoparticles, neoplasm, therapeutics, molecular imaging, tumor targeting.
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