Review on the Synthetic Methods of Biologically Potent Benzoxazole Derivatives

Author(s): Subramaniyan Arulmurugan, Helen P. Kavitha*, Jasmine P. Vennila

Journal Name: Mini-Reviews in Organic Chemistry

Volume 18 , Issue 6 , 2021

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Graphical Abstract:


Benzoxazole compounds have an important and broad range of biological activities. The benzoxazole and its substituted derivatives possess antimicrobial, antitumor, anti-inflammatory, antihistaminic, anti-parasitic, herbicidal, anti-allergic, anti-helmintic, anti-tubercular, anticonvulsant, hypoglycaemic, HIV-1 reverse transcriptase inhibitor and insecticidal activities. It has also been shown to have a binding affinity to Aβ42 fibrils. Such complex biological uses of benzoxazole compounds have inspired new efforts to find new derivatives with improved biological activity and different applications in the pharmaceutical industry. Due to outstanding relevance of this structure, the purpose of this analysis is to highlight aspects published in recent years (2000-2020) on the chemistry and biological activity of benzoxazoles.

Keywords: Benzoxazole, synthesis, antimicrobial activity, anti-inflammatory activity, anticancer activity, antitubercular activity.

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Article Details

Year: 2021
Published on: 20 October, 2020
Page: [769 - 785]
Pages: 17
DOI: 10.2174/1570193X17999201020231359
Price: $65

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