Autism is a highly inherited and extremely complex disorder in which results from various
cases indicate chromosome anomalies, unusual single-gene mutations, and multiplicative effects
of particular gene variants, characterized primarily by impaired speech and social interaction
and restricted behavior. The precise etiology of Autism Spectrum Disorder (ASD) is currently unclear.
The extracellular signal-regulated kinase (ERK) signaling mechanism affects neurogenesis
and neuronal plasticity during the development of the central nervous mechanism. In this regard,
the pathway of ERK has recently gained significant interest in the pathogenesis of ASD. The mutation
occurs in a few ERK components. Besides, the ERK pathway dysfunction lies in the upstream
of modified translation and contributes to synapse pathology in syndromic types of autism. In this
review, we highlight the ERK pathway as a target for neurodevelopmental disorder autism. In addition,
we summarize the regulation of the ERK pathway with ERK inhibitors in neurological disorders.
In conclusion, a better understanding of the ERK signaling pathway provides a range of therapeutic
options for autism spectrum disorder.