The Mitochondrion-Targeted Antioxidants in Kidney Disease

Author(s): Xinrui Li, Liang Ma*, Ping Fu

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 21 , 2021


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Abstract:

Mitochondria are a potent source of cellular reactive oxygen species (ROS) and are vulnerable to oxidative damage. Mitochondria dysfunction could result in adenosine triphosphate (ATP) decrease and cell death. The kidney is an ATP-consuming organ, and the relationship between mitochondrial dysfunction and renal disease has been long noted. Mitochondrial targeting is a novel strategy for kidney diseases. At present, there are several ways to target mitochondria, such as the addition of a triphenylphosphonium cation, mitochondria-targeted peptides, and nanocarrier. There are also a variety of choices for the payload, such as nitroxides, quinone derivates, vitamins and so on. This review summarized the chemical and also clinical characteristics of various mitochondria- targeted antioxidants and focused on their application and perspectives in kidney diseases.

Keywords: mitochondria-targeted, antioxidant, kidney disease, triphenylphosphonium, Szeto-Schiller peptides, hemigramicidin.

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Article Details

VOLUME: 28
ISSUE: 21
Year: 2021
Published on: 20 October, 2020
Page: [4190 - 4206]
Pages: 17
DOI: 10.2174/0929867327666201020151124
Price: $65

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