Aim: In this study, we evaluated the prognostic value of four calculated inflammatory
ratios in patients with colorectal cancer.
Materials and Methods: A six-year retrospective study was conducted on subjects admitted for
colorectal cancer at "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and
Hepatology Cluj-Napoca, Romania, from January 2014 until September 2019. The medical charts
of patients diagnosed with colorectal cancer were used as the source of raw data and for the
calculation of four ratios (neutrophil-to-lymphocyte ratio-NLR, derived neutrophil-to-lymphocyte
ratio-dNLR, platelet-to-lymphocyte ratio-PLR, and systemic immune-inflammation index-SII),
considered as prognostic markers related to mortality in colorectal cancer.
Results: One thousand six hundred and eighty-eight patients, with ages ranging from 17 to 98 years,
were evaluated. NLR and dNLR displayed significantly higher values among patients who died
(NLR: 4.2 for deceased vs. 3.4 for alive, P-value=0.0224; dNLR: 2.7 for deceased vs. 2.3 for alive, Pvalue=
0.0566). Ischemic cardiomyopathy (odds ratio (OR)=2.70), liver cirrhosis (OR=7.84), postoperative
complications (OR=2.39), and neutrophil-to-lymphocyte ratio (OR=1.08) proved to be
significant prognostic factors for the primary outcome, independent of age and gender.
Conclusion: Patients with high NLR, post-operative complications, ischemic cardiomyopathy,
and/or liver cirrhosis are the candidates to a less favorable outcome among subjects with colorectal
cancer regardless the age and gender.