The Pattern of Calculated Inflammation Ratios as Prognostic Values in Patients with Colorectal Cancer

Author(s): Andra Ciocan, Sorana D. Bolboacă*, Cristina Drugan, Răzvan A. Ciocan, Florin Graur, Nadim AL Hajjar

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24 , Issue 9 , 2021

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Aim: In this study, we evaluated the prognostic value of four calculated inflammatory ratios in patients with colorectal cancer.

Materials and Methods: A six-year retrospective study was conducted on subjects admitted for colorectal cancer at "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology Cluj-Napoca, Romania, from January 2014 until September 2019. The medical charts of patients diagnosed with colorectal cancer were used as the source of raw data and for the calculation of four ratios (neutrophil-to-lymphocyte ratio-NLR, derived neutrophil-to-lymphocyte ratio-dNLR, platelet-to-lymphocyte ratio-PLR, and systemic immune-inflammation index-SII), considered as prognostic markers related to mortality in colorectal cancer.

Results: One thousand six hundred and eighty-eight patients, with ages ranging from 17 to 98 years, were evaluated. NLR and dNLR displayed significantly higher values among patients who died (NLR: 4.2 for deceased vs. 3.4 for alive, P-value=0.0224; dNLR: 2.7 for deceased vs. 2.3 for alive, Pvalue= 0.0566). Ischemic cardiomyopathy (odds ratio (OR)=2.70), liver cirrhosis (OR=7.84), postoperative complications (OR=2.39), and neutrophil-to-lymphocyte ratio (OR=1.08) proved to be significant prognostic factors for the primary outcome, independent of age and gender.

Conclusion: Patients with high NLR, post-operative complications, ischemic cardiomyopathy, and/or liver cirrhosis are the candidates to a less favorable outcome among subjects with colorectal cancer regardless the age and gender.

Keywords: Inflammation ratios, colorectal cancer, prognostic factors, mortality, carcinogenesis, malignancies.

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Article Details

Year: 2021
Published on: 19 October, 2020
Page: [1428 - 1435]
Pages: 8
DOI: 10.2174/1386207323666201020111946
Price: $65

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