It has been a while since the disease of cancer was discovered in 16th and 17th century
but still, this disease is one of the most lethal diseases in the world, which is taking a great number
of lives every year. Cancer statistics suggest that there are still a lot of improvements that we have
to make in the field of cancer treatment in order to overcome this deadly disease. Currently,
nanotechnology has provided some more effective methods in this field, which has gained a lot of
attention. Novel drug delivery systems that work using nanoparticles might be the answer to many
unsolved questions in treating cancer. Chitosan is a natural glucose polymer which has the
potential to be utilized as a proper drug carrier due to its advantageous features. Chitosan-based
delivery systems are able to affect cancerous cells in many pathways. Wnt signaling pathways,
which are one of the most essential ingredients of cancer pathogenesis, can be the target of
chitosan nanoformulations. In this paper, we discussed the specific impacts of chitosan and its
nanoformulations on each component of the Wnt/catenin pathway. Our conclusions might give
novel insights for designing more efficient therapeutic approaches for several kinds of cancer.
Keywords: Wnt/catenin, signaling, colorectal, breast, ovarian, liver, chitosan, nanoparticle.
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