Metal-free organocatalysts are becoming an important tool for the sustainable development
of various bioactive heterocycles. On the other hand, during the last two decades,
calix[n]arenes have been gaining considerable attention due to their wide range of applicability
in the field of supramolecular chemistry. Recently, sulfonic acid functionalized calix[n]
arenes are being employed as an efficient alternative catalyst for the synthesis of various bioactive
scaffolds. In this review, we have summarized the catalytic efficiency of p-sulfonic
acid calix[n]arenes for the synthesis of diverse, biologically promising scaffolds under various
reaction conditions. There is no such review available in the literature showing the catalytic
applicability of p-sulfonic acid calix[n]arenes. Therefore, it is strongly believed that this
review will surely attract those researchers who are interested in this fascinating organocatalyst.
Keywords: p-Sulfonic acid calix[n]arenes, N-heterocycles, O-heterocycles, organocatalysis, bioactivity, scaffolds.
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